InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COL17A1

Summary

InnateDB Gene

IDBG-639390.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL17A1

Gene Name

Collagen alpha-1(XVII) chain 120 kDa linear IgA disease antigen homolog

Synonyms

BP180; BPAG2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002430

Encoded Proteins

IDBP-691591

Collagen alpha-1(XVII) chain120 kDa linear IgA disease antigen homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065618:
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:24848931-24896345

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013271

ENSBTAP00000013271

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0031581

hemidesmosome assembly

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005604	basement membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030056	hemidesmosome