Version 5.4
Bos taurus Gene: HAO1
Summary
InnateDB Gene IDBG-639976.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAO1
Gene Name hydroxyacid oxidase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019811
Encoded Proteins
IDBP-692187
hydroxyacid oxidase 1
IDBP-692190
hydroxyacid oxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101323:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51110902-51173199
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061291 ENSBTAP00000053733
ENSBTAT00000056526 ENSBTAP00000048395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0005102 receptor binding
GO:0008891 glycolate oxidase activity
GO:0010181 FMN binding
GO:0015930 glutamate synthase activity
GO:0016491 oxidoreductase activity
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006537 glutamate biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101323
View Gene Order
ENSMUSG00000027261
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16925
Glyoxylate metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_261828
Glyoxylate metabolism pathway
KEGG
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
hsa04146
Peroxisome pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.103776
RefSeq NM_001079781
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca