InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAMP2

Summary

InnateDB Gene

IDBG-640429.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAMP2

Gene Name

receptor activity-modifying protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019903

Encoded Proteins

IDBP-692689

receptor activity-modifying protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131477:
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:43441583-43443429

Strand

Forward strand

Band

Transcripts

ENSBTAT00000034789

ENSBTAP00000034674

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0015026	coreceptor activity

Biological Process

GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0002040	sprouting angiogenesis
GO:0006171	cAMP biosynthetic process
GO:0006816	calcium ion transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007507	heart development
GO:0008217	regulation of blood pressure
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0010628	positive regulation of gene expression
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0034333	adherens junction assembly
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043116	negative regulation of vascular permeability
GO:0045766	positive regulation of angiogenesis
GO:0070830	tight junction assembly
GO:0070831	basement membrane assembly
GO:0072659	protein localization to plasma membrane
GO:0097084	vascular smooth muscle cell development
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2001214	positive regulation of vasculogenesis