Version 5.4
Bos taurus Gene: INPP5E
Summary
InnateDB Gene IDBG-640481.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP5E
Gene Name 72 kDa inositol polyphosphate 5-phosphatase
Synonyms PMPCA
Species Bos taurus
Ensembl Gene ENSBTAG00000001354
Encoded Proteins
IDBP-692753
inositol polyphosphate-5-phosphatase, 72 kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148384:
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:103928312-103936269
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001784 ENSBTAP00000001784
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Biological Process
GO:0046488 phosphatidylinositol metabolic process
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005930 axoneme
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000148384
View Gene Order
ENSMUSG00000026925
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_198970
Synthesis of PIPs at the Golgi membrane pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BAU6
UniProt Splice Variant
Entrez Gene 506349
UniGene Bt.63449
RefSeq NM_001192090 XM_005213206 XM_005213207 XM_005213208
HUGO HGNC:21474
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02032322
GenPept
RNA Seq Atlas 506349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca