Version 5.4
| Homo sapiens Gene: IL1R2 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-64053.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | IL1R2 | ||||||||||||||||||
| Gene Name | interleukin 1 receptor, type II | ||||||||||||||||||
| Synonyms | CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2c; IL1RB | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000115590 | ||||||||||||||||||
| Encoded Proteins |
interleukin 1 receptor, type II
interleukin 1 receptor, type II
interleukin 1 receptor, type II
interleukin 1 receptor, type II
|
||||||||||||||||||
| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
IL1R2 binds to IL1A to limit post-necrotic inflammation.
|
||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
|
||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
||||||||||||||||||
| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 2:101991844-102028544 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q11.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
| Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
| Biological Process |
|
||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||
| Orthologs | |||||||||||||||||||
|
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH |
IL1 pathway
|
||||||||||||||||||
| REACTOME |
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
|
||||||||||||||||||
| KEGG |
Hematopoietic cell lineage pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Amoebiasis pathway
|
||||||||||||||||||
| INOH |
JAK STAT pathway and regulation pathway
|
||||||||||||||||||
| PID NCI |
IL1-mediated signaling events
|
||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.25333 | ||||||||||||||||||
| RefSeq | NM_001261419 NM_004633 XM_006712734 XM_006712736 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS2054 CCDS58719 | ||||||||||||||||||
| HPRD | 00995 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||