InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TULP3

Summary

InnateDB Gene

IDBG-640778.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TULP3

Gene Name

tubby-related protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015879

Encoded Proteins

IDBP-693073

tubby-related protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078246:
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:107343179-107373637

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021105

ENSBTAP00000021105

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0032403	protein complex binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001841	neural tube formation
GO:0001843	neural tube closure
GO:0007420	brain development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008589	regulation of smoothened signaling pathway
GO:0009952	anterior/posterior pattern specification
GO:0021904	dorsal/ventral neural tube patterning
GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021915	neural tube development
GO:0021953	central nervous system neuron differentiation
GO:0031076	embryonic camera-type eye development
GO:0042733	embryonic digit morphogenesis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048702	embryonic neurocranium morphogenesis
GO:0060173	limb development
GO:0060348	bone development
GO:0060434	bronchus morphogenesis
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061548	ganglion development
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0005930	axoneme
GO:0030991	intraciliary transport particle A
GO:0072372	primary cilium
GO:0097546	ciliary base

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000078246

View Gene Order

ENSMUSG00000001521

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228134

Signaling by Hedgehog pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_269412

Hedgehog 'off' state pathway

REACT_250064

Signaling by Hedgehog pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.6709

RefSeq

NM_001098992 XM_005207248 XM_005207249 XM_005207250

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas