Version 5.4
Bos taurus Gene: CISD2
Summary
InnateDB Gene IDBG-640805.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CISD2
Gene Name CDGSH iron-sulfur domain-containing protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000027630
Encoded Proteins
IDBP-693099
CDGSH iron-sulfur domain-containing protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145354:
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:23289384-23302661
Strand Reverse strand
Band
Transcripts
ENSBTAT00000039792 ENSBTAP00000039580
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0006914 autophagy
GO:0010259 multicellular organismal aging
GO:0010506 regulation of autophagy
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145354
View Gene Order
ENSMUSG00000028165
View Gene Order
Cross-References
SwissProt Q05B71
TrEMBL
UniProt Splice Variant
Entrez Gene 781260
UniGene
RefSeq NM_001080338
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122676
GenPept AAI22677
RNA Seq Atlas 781260

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca