Version 5.4
Homo sapiens Gene: MBOAT1
Summary
InnateDB Gene IDBG-64116.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBOAT1
Gene Name membrane bound O-acyltransferase domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172197
Encoded Proteins
IDBP-64118
membrane bound O-acyltransferase domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in membranes. A translocation disrupting this gene may be associated with brachydactyly syndactyly syndrome. Alternately spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:20102145-20212399
Strand Reverse strand
Band p22.3
Transcripts
ENST00000324607 ENSP00000324944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038732
View Gene Order
ENSBTAG00000016519
Not yet available
Pathways
NETPATH
REACTOME
REACT_121384
Acyl chain remodelling of PS pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q6ZNC8
TrEMBL
UniProt Splice Variant
Entrez Gene 154141
UniGene
RefSeq NM_001080480
HUGO HGNC:21579
OMIM 138670 611732
CCDS CCDS34346
HPRD
IMGT
EMBL AB305043 AK093994 AK131269 AK296857 AK304748 AL008627 AL158198 AL355139 BC150650 BC150652
GenPept AAI50651 AAI50653 BAC04264 BAD18447 BAF93899 BAG59421 BAG65506 CAH71585 CAI19512 CAI20913
RNA Seq Atlas 154141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca