Bos taurus Gene: GNAS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-641209.3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Symbol | GNAS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Name | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000017475 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087460:
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012] This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5\' exons. Some transcripts contain a differentially methylated region (DMR) at their 5\' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 13:58010287-58049012 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
REACTOME |
Aquaporin-mediated transport pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Regulation of insulin secretion pathway
Glucagon-type ligand receptors pathway
Signaling by GPCR pathway
G alpha (s) signalling events pathway
Prostacyclin signalling through prostacyclin receptor pathway
Hemostasis pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
G alpha (i) signalling events pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
Platelet homeostasis pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Signaling by Hedgehog pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Class B/2 (Secretin family receptors) pathway
G alpha (z) signalling events pathway
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KEGG | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NETPATH |
TSH pathway
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REACTOME |
Prostacyclin signalling through prostacyclin receptor pathway
Platelet homeostasis pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
G alpha (i) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Glucagon-type ligand receptors pathway
Class B/2 (Secretin family receptors) pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Signaling by Hedgehog pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Hedgehog 'off' state pathway
GPCR ligand binding pathway
Metabolism pathway
Aquaporin-mediated transport pathway
Hemostasis pathway
G alpha (s) signalling events pathway
Glucagon-type ligand receptors pathway
GPCR downstream signaling pathway
Platelet homeostasis pathway
Hemostasis pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Hedgehog 'off' state pathway
Class B/2 (Secretin family receptors) pathway
Integration of energy metabolism pathway
Metabolism pathway
PKA activation in glucagon signalling pathway
Aquaporin-mediated transport pathway
Regulation of insulin secretion pathway
Prostacyclin signalling through prostacyclin receptor pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
GPCR ligand binding pathway
G alpha (z) signalling events pathway
Transmembrane transport of small molecules pathway
G alpha (i) signalling events pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
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KEGG |
GnRH signaling pathway pathway
Vibrio cholerae infection pathway
Gap junction pathway
Taste transduction pathway
Long-term depression pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Dilated cardiomyopathy pathway
Vasopressin-regulated water reabsorption pathway
Gastric acid secretion pathway
Amoebiasis pathway
Chagas disease (American trypanosomiasis) pathway
Pancreatic secretion pathway
Salivary secretion pathway
Bile secretion pathway
Taste transduction pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Gap junction pathway
GnRH signaling pathway pathway
Long-term depression pathway
Vascular smooth muscle contraction pathway
Dilated cardiomyopathy pathway
Vasopressin-regulated water reabsorption pathway
Amoebiasis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Bile secretion pathway
Pancreatic secretion pathway
Chagas disease (American trypanosomiasis) pathway
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INOH |
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
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PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SwissProt | P04896 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TrEMBL | F1N0T0 G1K1V2 G9BHS5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | 281793 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
EMBL | BC102905 BC122757 DAAA02036326 DAAA02036327 DAAA02036328 HQ585496 M13006 M14014 X03404 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GenPept | AAA30557 AAA30560 AAI02906 AAI22758 AEA11434 CAA27137 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 281793 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||