InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: E2F3

Summary

InnateDB Gene

IDBG-64143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F3

Gene Name

E2F transcription factor 3

Synonyms

E2F-3

Species

Homo sapiens

Ensembl Gene

ENSG00000112242

Encoded Proteins

IDBP-64147

E2F transcription factor 3

IDBP-585517

E2F transcription factor 3

IDBP-809423

E2F transcription factor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a small family of transcriptional factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate expression of cell-cycle genes. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:20401906-20493715

Strand

Forward strand

Band

p22.3

Transcripts

ENST00000346618	ENSP00000262904
ENST00000535432	ENSP00000443418
ENST00000613242	ENSP00000483249

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	46 [view]
Protein-DNA	17 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000085	mitotic G2 phase
GO:0000278	mitotic cell cycle
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle