Version 5.4
Bos taurus Gene: TRIB3
Summary
InnateDB Gene IDBG-641473.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIB3
Gene Name Tribbles homolog 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017007
Encoded Proteins
IDBP-693841
Tribbles homolog 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21220698
[Homo sapiens] TRIB3 is an inhibitor of TLR2 mediated NFKB activation and chemokine induction. Helicobacter pylori LPS stimulation decrease expression of TRIB3, which may be an important mechanism during H. pylori-associated pathogenesis.
PMID 21220698
[Mus musculus] TRIB3 is an inhibitor of TLR2 mediated NFKB activation and chemokine induction. Helicobacter pylori LPS stimulation decrease expression of TRIB3, which may be an important mechanism during H. pylori-associated pathogenesis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101255:
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:61176218-61187210
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022616 ENSBTAP00000022616
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0055106 ubiquitin-protein ligase regulator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006915 apoptotic process
GO:0010827 regulation of glucose transport
GO:0032092 positive regulation of protein binding
GO:0032869 cellular response to insulin stimulus
GO:0034976 response to endoplasmic reticulum stress
GO:0043405 regulation of MAP kinase activity
GO:0045599 negative regulation of fat cell differentiation
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101255
View Gene Order
ENSMUSG00000032715
View Gene Order
Pathways
NETPATH
REACTOME
REACT_217956
DAP12 interactions pathway
REACT_206974
Insulin receptor signalling cascade pathway
REACT_217559
CD28 dependent PI3K/Akt signaling pathway
REACT_208036
Signaling by EGFR pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_222082
GAB1 signalosome pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_204365
Signaling by PDGF pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_213843
Costimulation by the CD28 family pathway
REACT_224994
Activation of PKB pathway
REACT_202837
Signaling by FGFR pathway
REACT_208835
IRS-related events pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_215558
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_219416
PI3K events in ERBB2 signaling pathway
REACT_213138
Immune System pathway
REACT_224404
IRS-mediated signalling pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_224780
CD28 co-stimulation pathway
REACT_205435
Signaling by the B Cell Receptor (BCR) pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214353
Signal Transduction pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_209911
PI3K Cascade pathway
REACT_219546
Signaling by Insulin receptor pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_204467
PI-3K cascade pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_211053
Negative regulation of the PI3K/AKT network pathway
REACT_222492
PI3K events in ERBB4 signaling pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_219139
Metabolism pathway
REACT_207066
Signalling by NGF pathway
REACT_226693
Signaling by VEGF pathway
REACT_221870
PI3K/AKT Signaling in Cancer pathway
REACT_224097
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_214469
Adaptive Immune System pathway
REACT_212750
Downstream signal transduction pathway
REACT_207237
PPARA activates gene expression pathway
REACT_208171
PIP3 activates AKT signaling pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_225332
PI3K/AKT activation pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_12447
Negative regulation of the PI3K/AKT network pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12464
PI3K/AKT activation pathway
REACT_790
Activation of PKB pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_12529
Signaling by VEGF pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_111217
Metabolism pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_226151
CD28 dependent PI3K/Akt signaling pathway
REACT_189085
Disease pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_227951
Signaling by VEGF pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_240075
Activation of PKB pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_214733
Negative regulation of the PI3K/AKT network pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_204081
CD28 co-stimulation pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_240139
PI3K Cascade pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_198602
PPARA activates gene expression pathway
REACT_206286
GAB1 signalosome pathway
REACT_243154
IRS-related events pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242206
IRS-mediated signalling pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q0VCE3
TrEMBL
UniProt Splice Variant
Entrez Gene 538465
UniGene Bt.45499
RefSeq NM_001076103 XM_005214812
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120209
GenPept AAI20210
RNA Seq Atlas 538465

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca