Version 5.4
Homo sapiens Gene: ERAS
Summary
InnateDB Gene IDBG-64196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERAS
Gene Name ES cell expressed Ras
Synonyms HRAS2; HRASP
Species Homo sapiens
Ensembl Gene ENSG00000187682
Encoded Proteins
IDBP-64198
ES cell expressed Ras
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48828873-48830138
Strand Forward strand
Band p11.23
Transcripts
ENST00000338270 ENSP00000339136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031160
View Gene Order
ENSBTAG00000012954
Not yet available
Cross-References
SwissProt Q7Z444
TrEMBL
UniProt Splice Variant
Entrez Gene 3266
UniGene Hs.447330 Hs.742965
RefSeq NM_181532
HUGO HGNC:5174
OMIM 300437
CCDS CCDS35246
HPRD
IMGT
EMBL AB093575 BC101642 BC101644
GenPept AAI01643 AAI01645 BAC76997
RNA Seq Atlas 3266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca