Version 5.4
Homo sapiens Gene: IL18R1
Summary
InnateDB Gene IDBG-64199.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL18R1
Gene Name interleukin 18 receptor 1
Synonyms CD218a; CDw218a; IL-1Rrp; IL18RA; IL1RRP
Species Homo sapiens
Ensembl Gene ENSG00000115604
Encoded Proteins
IDBP-64201
interleukin 18 receptor 1
IDBP-64203
interleukin 18 receptor 1
IDBP-295103
interleukin 18 receptor 1
IDBP-295111
interleukin 18 receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25654981
IL37 acts as an extracellular cytokine to inhibit innate inflammation by binding to IL18R1 and then using IL1RAPL1 for its anti-inflammatory properties.
Entrez Gene
Summary The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:102311529-102398775
Strand Forward strand
Band q12.1
Transcripts
ENST00000233957 ENSP00000233957
ENST00000334376 ENSP00000334030
ENST00000410040 ENSP00000386663
ENST00000409599 ENSP00000387211
ENST00000466357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 6 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004908 interleukin-1 receptor activity
GO:0005515 protein binding
GO:0042008 interleukin-18 receptor activity
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0030101 natural killer cell activation
GO:0032729 positive regulation of interferon-gamma production
GO:0035655 interleukin-18-mediated signaling pathway
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0045063 T-helper 1 cell differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026070
View Gene Order
ENSBTAG00000001034
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt Q13478
TrEMBL B7ZKV7
UniProt Splice Variant
Entrez Gene 8809
UniGene Hs.469521 Hs.737999
RefSeq NM_001282399 NM_003855 XM_005264039 XM_006712823
HUGO HGNC:5988
OMIM 604494
CCDS CCDS2060
HPRD 05138
IMGT
EMBL AC007248 AK313967 BC069575 BC093975 BC093977 BC143403 U43672
GenPept AAC50390 AAH69575 AAH93975 AAH93977 AAI43404 AAY15048 BAG36682
RNA Seq Atlas 8809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca