Bos taurus Gene: SRP72
Summary
InnateDB Gene IDBG-642578.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRP72
Gene Name signal recognition particle 72 kDa protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010593
Encoded Proteins
signal recognition particle 72kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174780:
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:73511906-73537572
Strand Forward strand
Band
Transcripts
ENSBTAT00000014015 ENSBTAP00000014015
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005047 signal recognition particle binding
GO:0005515 protein binding
GO:0008312 7S RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0042493 response to drug
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0030529 ribonucleoprotein complex
GO:0048500 signal recognition particle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
SRP-dependent cotranslational protein targeting to membrane pathway
Translation pathway
Metabolism of proteins pathway
Gene Expression pathway
KEGG
Protein export pathway
Protein export pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E1BB38
UniProt Splice Variant
Entrez Gene 509430
UniGene Bt.11924
RefSeq NM_001192221 XM_005207951 XM_005207952
HUGO HGNC:11303
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02017740
GenPept
RNA Seq Atlas 509430
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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