InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PQBP1

Summary

InnateDB Gene

IDBG-64349.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PQBP1

Gene Name

polyglutamine binding protein 1

Synonyms

MRX2; MRX55; MRXS3; MRXS8; NPW38; RENS1; SHS

Species

Homo sapiens

Ensembl Gene

ENSG00000102103

Encoded Proteins

IDBP-64351

polyglutamine binding protein 1

IDBP-64355

polyglutamine binding protein 1

IDBP-64357

polyglutamine binding protein 1

IDBP-64359

polyglutamine binding protein 1

IDBP-236798

polyglutamine binding protein 1

IDBP-370871

polyglutamine binding protein 1

IDBP-370879

polyglutamine binding protein 1

IDBP-370890

polyglutamine binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26046437

PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with MB21D1 to initiate an IRF3-dependent innate response.

Entrez Gene

Summary

This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:48897912-48903143

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000376566	ENSP00000365750
ENST00000376563	ENSP00000365747
ENST00000218224	ENSP00000218224
ENST00000247140	ENSP00000247140
ENST00000396763	ENSP00000379985
ENST00000447146	ENSP00000391759
ENST00000443648	ENSP00000414861
ENST00000456306	ENSP00000393013
ENST00000473764
ENST00000472742
ENST00000486150
ENST00000477997
ENST00000470062
ENST00000474671
ENST00000463529
ENST00000470059
ENST00000465859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0031175	neuron projection development
GO:0034063	stress granule assembly
GO:0043484	regulation of RNA splicing
GO:0045087	innate immune response (InnateDB)
GO:0048814	regulation of dendrite morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0016607	nuclear speck
GO:0071598	neuronal ribonucleoprotein granule

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031157

View Gene Order

ENSBTAG00000018498

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001032381 NM_001032382 NM_001032383 NM_001032384 NM_001167989 NM_001167990 NM_005710 NM_144495 XM_005272571 XM_005272572

HUGO

OMIM

CCDS

CCDS14309 CCDS55412

HPRD

02354

IMGT

EMBL

GenPept

RNA Seq Atlas