Version 5.4
Bos taurus Gene: EXOSC4
Summary
InnateDB Gene IDBG-643652.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOSC4
Gene Name Exosome complex component RRP41
Synonyms RRP41
Species Bos taurus
Ensembl Gene ENSBTAG00000014607
Encoded Proteins
IDBP-696220
Exosome complex component RRP41
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178896:
Gene Information
Type Protein coding
Genomic Location Chromosome 14:1947198-1949074
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019451 ENSBTAP00000019451
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0017091 AU-rich element binding
Biological Process
GO:0000460 maturation of 5.8S rRNA
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006364 rRNA processing
GO:0030307 positive regulation of cell growth
GO:0045006 DNA deamination
GO:0051607 defense response to virus
GO:0071028 nuclear mRNA surveillance
GO:0071044 histone mRNA catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0035327 transcriptionally active chromatin
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000178896
View Gene Order
ENSMUSG00000034259
View Gene Order
Pathways
NETPATH
REACTOME
REACT_212709
KSRP destabilizes mRNA pathway
REACT_207291
PERK regulates gene expression pathway
REACT_226413
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_204438
ATF4 activates genes pathway
REACT_226022
Gene Expression pathway
REACT_213782
Metabolism of proteins pathway
REACT_220156
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
REACT_203426
Deadenylation-dependent mRNA decay pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_25042
KSRP destabilizes mRNA pathway
REACT_20619
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_17015
Metabolism of proteins pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
REACT_252013
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198696
KSRP destabilizes mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q7YRA3
TrEMBL
UniProt Splice Variant
Entrez Gene 618292
UniGene Bt.16597
RefSeq NM_001078086
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ518955 BC109819
GenPept AAI09820 CAD58792
RNA Seq Atlas 618292

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca