Version 5.4
Homo sapiens Gene: POU3F3
Summary
InnateDB Gene IDBG-64389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POU3F3
Gene Name POU class 3 homeobox 3
Synonyms BRN1; OTF8
Species Homo sapiens
Ensembl Gene ENSG00000198914
Encoded Proteins
IDBP-64391
POU class 3 homeobox 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary POU3F3 is a member of the class III POU family of transcription factors (see POU3F1; MIM 602479) that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences (summarized by Sumiyama et al., 1996 [PubMed 8703082]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:104855511-104860471
Strand Forward strand
Band q12.1
Transcripts
ENST00000361360 ENSP00000355001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0071837 HMG box domain binding
Biological Process
GO:0001822 kidney development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007417 central nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021869 forebrain ventricular zone progenitor cell division
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0072218 metanephric ascending thin limb development
GO:0072227 metanephric macula densa development
GO:0072233 metanephric thick ascending limb development
GO:0072236 metanephric loop of Henle development
GO:0072240 metanephric DCT cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000045515
View Gene Order
Cross-References
SwissProt P20264
TrEMBL
UniProt Splice Variant
Entrez Gene 5455
UniGene Hs.248158 Hs.590899 Hs.673855
RefSeq NM_006236
HUGO HGNC:9216
OMIM 602480
CCDS CCDS33265
HPRD
IMGT
EMBL AB001835 AC018730
GenPept AAX88973 BAA19459
RNA Seq Atlas 5455

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca