Version 5.4
| Bos taurus Gene: BT.26220 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-644222.3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | BT.26220 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | transcription factor p65 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000013895 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
transcription factor p65
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] RELA, NF-kappaB p65 subunit, is involved in the transcription regulation of many genes including those genes involved in apoptosis, response to stress and inflammation.
[Homo sapiens] RELA is a subunit of NFKB and is not essential for virus-stimulated IFNB expression, instead, RELA sustains autocrine IFNB signalling prior to infection. The absence of RELA causes significant delays in IFNB induction and consequently defective secondary antiviral gene expression. RELA maintains autocrine IFNB signalling in uninfected cells, facilitates inflammatory and adaptive immune responses following infection, and promotes infected cell survival during this process.
[Homo sapiens] RELA is critical for pulmonary host defence during Streptococcus pneumoniae pneumonia in alveolar macrophages. During pneumococcal pneumonia, only the earliest induction of cytokines depends on transcription regulated by RELA in myeloid cells, and this transcriptional activity contributes to effective immunity. (Demonstrated in murine model)
[Homo sapiens] RELA is required for IL17A production in T cell in response to bacterial infection. RELA deficient T cells resulted in a diminished innate immune response to E. coli infection. (Demonstrated in murine model)
[Homo sapiens] A RELA isoform, p43, lacks the transactivation domain but is still able to potentiate anti-viral innate immunity.
[Homo sapiens] During the transcriptional response to Sendai virus infection, POLR2F(RNA Pol II) is recruited by IRF3 and NFκB to control virus induced gene activation.
[Homo sapiens] Paramyxoviruses trigger the DNA-damage response, a pathway required for RPS6KA5 activation of phospho Ser 276 RELA formation to trigger the IRF7-DDX58 amplification loop necessary for mucosal interferon production.
[Homo sapiens] Human papillomaviruses impair the acetylation of NFκB/RelA K310 in keratinocytes by augmenting the expression of interferon-related developmental regulator 1 (IFRD1) in an EGFR-dependent manner.
[Homo sapiens] Haploinsufficiency of A20 (HA20) is caused by high-penetrance loss-of-function germline mutations in TNFAIP3 with increased degradation of NFKBIA, nuclear translocation of RELA, increased expression of NFκB mediated proinflammatory cytokines, and defective deubiquitinating activity.
[Homo sapiens] MIR223 regulates macrophage function by modulating cytokine production and NF-κB activation through inhibition of RELA phosphorylation and nuclear translocation.
[Homo sapiens] Enterovirus 71 2C protein binds to RELA and IKBKB to inhibit NF-kB activation and evade innate immune defenses.
[Mus musculus] Rela is a subunit of NFKB and is not essential for virus-stimulated Ifnb expression, instead, Rela sustains autocrine Ifnb signaling prior to infection. The absence of Rela causes significant delays in Ifnb induction and consequently defective secondary antiviral gene expression. Rela maintains autocrine Ifnb signaling in uninfected cells, facilitates inflammatory and adaptive immune responses following infection, and promotes infected cell survival during this process.
[Mus musculus] Rela is critical for pulmonary host defense during Streptococcus pneumoniae pneumonia in alveolar macrophages. During pneumococcal pneumonia, only the earliest induction of cytokines depends on transcription regulated by Rela in myeloid cells, and this transcriptional activity contributes to effective immunity.
[Mus musculus] Rela is required for Il17a production in T cell in response to bacterial infection. Rela deficient T cells resulted in a diminished innate immune response to E. coli infection.
[Mus musculus] Tnfaip3 is regulated by both Nf-κB and p38-dependent Cebpb in response to LPS in macrophages.
[Mus musculus] The noncanonical NFκB pathway regulates histone modifications at the Ifnb1 promoter resulting in attenuated recruitment of Rela and histone demethylase, Kdm4a, to the Ifnb1 promoter. This provides a mechanism for regulating the induction of type I interferons .
[Mus musculus] Lysophosphatidic acid plays an anti-inflammatory role in macrophages by diminishing lipopolysaccharide-induced phosphorylation of Mapk14 and Akt1, as well as Rela nuclear translocation.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173039:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 29:44496359-44505000 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 374 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
Notch pathway
EGFR1 pathway
KitReceptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL4 pathway
RANKL pathway
Leptin pathway
TSH pathway
TSLP pathway
FSH pathway
TWEAK pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
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| REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Downstream TCR signaling pathway
Interleukin-1 processing pathway
Activation of NF-kappaB in B cells pathway
Regulated proteolysis of p75NTR pathway
NF-kB is activated and signals survival pathway
Transcriptional regulation of white adipocyte differentiation pathway
Cellular responses to stress pathway
Developmental Biology pathway
FCERI mediated NF-kB activation pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
Adaptive Immune System pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream TCR signaling pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
FCERI mediated NF-kB activation pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Activation of NF-kappaB in B cells pathway
Fc epsilon receptor (FCERI) signaling pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
p75NTR signals via NF-kB pathway
Interleukin-1 processing pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Signalling by NGF pathway
RIP-mediated NFkB activation via ZBP1 pathway
Adaptive Immune System pathway
NF-kB is activated and signals survival pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
Regulated proteolysis of p75NTR pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
TCR signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Acute myeloid leukemia pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Apoptosis pathway
MAPK signaling pathway pathway
Small cell lung cancer pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Chronic myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Leishmaniasis pathway
Amoebiasis pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Shigellosis pathway
Toxoplasmosis pathway
Hepatitis C pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
MAPK signaling pathway pathway
Small cell lung cancer pathway
Adipocytokine signaling pathway pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Leishmaniasis pathway
Amoebiasis pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
TNFR1 signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
TNFR1 signaling pathway pathway
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| PID NCI |
CD40/CD40L signaling
Atypical NF-kappaB pathway
Ceramide signaling pathway
LPA receptor mediated events
IL1-mediated signaling events
TNF receptor signaling pathway
IL12-mediated signaling events
Signaling events mediated by HDAC Class I
Glucocorticoid receptor regulatory network
p73 transcription factor network
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
IL23-mediated signaling events
Canonical NF-kappaB pathway
Fc-epsilon receptor I signaling in mast cells
IL2 signaling events mediated by PI3K
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Osteopontin-mediated events
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | A1XG22 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 508233 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Bt.111988 Bt.26220 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001080242 XM_005227026 XM_005227027 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | BC133594 DAAA02063569 DQ355511 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | AAI33595 ABC75820 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 508233 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||