InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COL4A3

Summary

InnateDB Gene

IDBG-644230.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL4A3

Gene Name

collagen alpha-3(IV) chain precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021316

Encoded Proteins

IDBP-696859

collagen alpha-3(IV) chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169031:
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:116131000-116291205

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028418

ENSBTAP00000028418

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0008283	cell proliferation
GO:0016525	negative regulation of angiogenesis
GO:0032836	glomerular basement membrane development
GO:0072577	endothelial cell apoptotic process