Homo sapiens Gene: PRKCI
Summary
InnateDB Gene IDBG-64428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKCI
Gene Name protein kinase C, iota
Synonyms DXS1179E; nPKC-iota; PKCI;
Species Homo sapiens
Ensembl Gene ENSG00000163558
Encoded Proteins
protein kinase C, iota
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:170222365-170305981
Strand Forward strand
Band q26.2
Transcripts
ENST00000295797 ENSP00000295797
ENST00000488541
ENST00000493761
ENST00000482353
ENST00000476635
ENST00000485837
ENST00000483697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 100 [view]
Protein-Protein 98 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0008270 zinc ion binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019904 protein domain specific binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006612 protein targeting to membrane
GO:0007010 cytoskeleton organization
GO:0007015 actin filament organization
GO:0010976 positive regulation of neuron projection development
GO:0016192 vesicle-mediated transport
GO:0016477 cell migration
GO:0032869 cellular response to insulin stimulus
GO:0034329 cell junction assembly
GO:0034351 negative regulation of glial cell apoptotic process
GO:0034613 cellular protein localization
GO:0035089 establishment of apical/basal cell polarity
GO:0035556 intracellular signal transduction
GO:0042462 eye photoreceptor cell development
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045216 cell-cell junction organization
GO:0046326 positive regulation of glucose import
GO:0046903 secretion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048194 Golgi vesicle budding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060252 positive regulation of glial cell proliferation
GO:0061024 membrane organization
GO:0070555 response to interleukin-1
GO:0070830 tight junction assembly
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0000133 polarisome
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0015630 microtubule cytoskeleton
GO:0016324 apical plasma membrane
GO:0031252 cell leading edge
GO:0043220 Schmidt-Lanterman incisure
GO:0043234 protein complex
GO:0045171 intercellular bridge
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Signalling by NGF pathway
p75NTR recruits signalling complexes pathway
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
Cell-cell junction organization pathway
KEGG
Endocytosis pathway
Tight junction pathway
Insulin signaling pathway pathway
INOH
GPCR signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478199 Hs.600112 Hs.609198
RefSeq NM_002740
HUGO
OMIM
CCDS CCDS3212
HPRD 02105
IMGT
EMBL
GenPept
RNA Seq Atlas