InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKCI

Summary

InnateDB Gene

IDBG-64428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKCI

Gene Name

protein kinase C, iota

Synonyms

DXS1179E; nPKC-iota; PKCI

Species

Homo sapiens

Ensembl Gene

ENSG00000163558

Encoded Proteins

IDBP-64430

protein kinase C, iota

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:170222365-170305981

Strand

Forward strand

Band

q26.2

Transcripts

ENST00000295797	ENSP00000295797
ENST00000488541
ENST00000493761
ENST00000482353
ENST00000476635
ENST00000485837
ENST00000483697

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019904	protein domain specific binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006612	protein targeting to membrane
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0010976	positive regulation of neuron projection development
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0032869	cellular response to insulin stimulus
GO:0034329	cell junction assembly
GO:0034351	negative regulation of glial cell apoptotic process
GO:0034613	cellular protein localization
GO:0035089	establishment of apical/basal cell polarity
GO:0035556	intracellular signal transduction
GO:0042462	eye photoreceptor cell development
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045216	cell-cell junction organization
GO:0046326	positive regulation of glucose import
GO:0046903	secretion
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048194	Golgi vesicle budding
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060252	positive regulation of glial cell proliferation
GO:0061024	membrane organization
GO:0070555	response to interleukin-1
GO:0070830	tight junction assembly
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0000133	polarisome
GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0015630	microtubule cytoskeleton
GO:0016324	apical plasma membrane
GO:0031252	cell leading edge
GO:0043220	Schmidt-Lanterman incisure
GO:0043234	protein complex
GO:0045171	intercellular bridge
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome