InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP5A1

Summary

InnateDB Gene

IDBG-644576.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5A1

Gene Name

ATP synthase subunit alpha, mitochondrial precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002507

Encoded Proteins

IDBP-697222

ATP synthase subunit alpha, mitochondrial precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152234:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:46300459-46309366

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003259

ENSBTAP00000003259

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887	ATPase activity
GO:0042288	MHC class I protein binding
GO:0044822	poly(A) RNA binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006200	ATP catabolic process
GO:0006629	lipid metabolic process
GO:0006754	ATP biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0046034	ATP metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062	extracellular vesicular exosome