InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.65963

Summary

InnateDB Gene

IDBG-645105.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.65963

Gene Name

7-dehydrocholesterol reductase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016465

Encoded Proteins

IDBP-697789

7-dehydrocholesterol reductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26938778

[Mus musculus] Mir342 is involved in a novel post-transcriptional viral defence mechanism in IFN-activated macrophages by directly targeting Srebf2, Idi1, Dhcr7 and Sc4mol of the sterol pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172893:
This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:48930324-48950644

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021892

ENSBTAP00000021892

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0047598	7-dehydrocholesterol reductase activity

Biological Process

GO:0001568	blood vessel development
GO:0009791	post-embryonic development
GO:0016126	sterol biosynthetic process
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0035264	multicellular organism growth
GO:0042127	regulation of cell proliferation
GO:0055114	oxidation-reduction process