InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AP3B1

Summary

InnateDB Gene

IDBG-645194.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP3B1

Gene Name

AP-3 complex subunit beta-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005016

Encoded Proteins

IDBP-697887

AP-3 complex subunit beta-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21045126

[Homo sapiens] AP3B1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal TLR7 or TLR9.

PMID 21119105

[Homo sapiens] AP3B1 is crucial for the trafficking of TLR9 to specific endosomal compartments for the induction of type I interferon.

PMID 21045126

[Mus musculus] Ap3b1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal Tlr7 or Tlr9.

PMID 21119105

[Mus musculus] Ap3b1 is crucial for the trafficking of Tlr9 to specific endosomal compartments for the induction of type I interferon.

PMID 26423153

[Mus musculus] Cytokine activation as a result of Tlr2 stimulation is mediated by the phagosomal trafficking molecule Ap3b1 (AP-3).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132842:
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:9040253-9300567

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006605

ENSBTAP00000006605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0019903	protein phosphatase binding
GO:0030742	GTP-dependent protein binding

Biological Process

GO:0006622	protein targeting to lysosome
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0007596	blood coagulation
GO:0008089	anterograde axon cargo transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0019882	antigen processing and presentation
GO:0032438	melanosome organization
GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048490	anterograde synaptic vesicle transport
GO:0051138	positive regulation of NK T cell differentiation

Cellular Component

GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030123	AP-3 adaptor complex
GO:0030665	clathrin-coated vesicle membrane
GO:0031410	cytoplasmic vesicle