Version 5.4
| Bos taurus Gene: SDC2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-645204.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | SDC2 | ||||||||
| Gene Name | Syndecan-2 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000014357 | ||||||||
| Encoded Proteins |
Syndecan-2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169439:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 14:69930853-70050653 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Defective EXT2 causes exostoses 2 pathway
Defective CHST6 causes MCDC1 pathway
MPS IIIA - Sanfilippo syndrome A pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
Glycosaminoglycan metabolism pathway
Non-integrin membrane-ECM interactions pathway
Defective CHSY1 causes TPBS pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIID - Sanfilippo syndrome D pathway
Diseases associated with glycosaminoglycan metabolism pathway
Extracellular matrix organization pathway
Retinoid metabolism and transport pathway
MPS IX - Natowicz syndrome pathway
Myoclonic epilepsy of Lafora pathway
MPS II - Hunter syndrome pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
MPS VII - Sly syndrome pathway
Visual phototransduction pathway
Defective B3GAT3 causes JDSSDHD pathway
EPH-Ephrin signaling pathway
Mucopolysaccharidoses pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Diseases of glycosylation pathway
HS-GAG degradation pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Axon guidance pathway
MPS IIIC - Sanfilippo syndrome C pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Defective CHST3 causes SEDCJD pathway
Metabolism pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective SLC26A2 causes chondrodysplasias pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome A pathway
Syndecan interactions pathway
EPHB-mediated forward signaling pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
MPS IV - Morquio syndrome B pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Disease pathway
Developmental Biology pathway
HS-GAG biosynthesis pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
TGF_beta_Receptor pathway
Hedgehog pathway
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| REACTOME |
Retinoid metabolism and transport pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
HS-GAG degradation pathway
HS-GAG biosynthesis pathway
Developmental Biology pathway
Mucopolysaccharidoses pathway
Myoclonic epilepsy of Lafora pathway
Extracellular matrix organization pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
EPHB-mediated forward signaling pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
Syndecan interactions pathway
Axon guidance pathway
Defective SLC26A2 causes chondrodysplasias pathway
Signal Transduction pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
Diseases associated with visual transduction pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Non-integrin membrane-ECM interactions pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Visual phototransduction pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS VII - Sly syndrome pathway
EPH-Ephrin signaling pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Glycosaminoglycan metabolism pathway
Syndecan interactions pathway
Disease pathway
Retinoid metabolism and transport pathway
HS-GAG degradation pathway
MPS IV - Morquio syndrome B pathway
MPS IV - Morquio syndrome A pathway
Chondroitin sulfate/dermatan sulfate metabolism pathway
MPS IIIC - Sanfilippo syndrome C pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
Extracellular matrix organization pathway
MPS IIID - Sanfilippo syndrome D pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Diseases of glycosylation pathway
Defective CHSY1 causes TPBS pathway
Defective B3GAT3 causes JDSSDHD pathway
MPS II - Hunter syndrome pathway
Diseases associated with glycosaminoglycan metabolism pathway
A tetrasaccharide linker sequence is required for GAG synthesis pathway
HS-GAG biosynthesis pathway
Heparan sulfate/heparin (HS-GAG) metabolism pathway
EPH-Ephrin signaling pathway
MPS IX - Natowicz syndrome pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Glycogen storage diseases pathway
MPS VII - Sly syndrome pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Defective CHST3 causes SEDCJD pathway
Developmental Biology pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
MPS IIIB - Sanfilippo syndrome B pathway
MPS IIIA - Sanfilippo syndrome A pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Defective PAPSS2 causes SEMD-PA pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Mucopolysaccharidoses pathway
Defective CHST6 causes MCDC1 pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Defective EXT2 causes exostoses 2 pathway
Defective SLC26A2 causes chondrodysplasias pathway
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| KEGG |
Cell adhesion molecules (CAMs) pathway
Malaria pathway
Cell adhesion molecules (CAMs) pathway
Malaria pathway
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| INOH |
Integrin signaling pathway pathway
Wnt signaling pathway pathway
Integrin signaling pathway pathway
Wnt signaling pathway pathway
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| PID NCI |
Syndecan-2-mediated signaling events
Proteoglycan syndecan-mediated signaling events
FGF signaling pathway
SHP2 signaling
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| Cross-References | |||||||||
| SwissProt | Q58DD4 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 615785 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_001034788 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC112468 BT021663 | ||||||||
| GenPept | AAI12469 AAX46510 | ||||||||
| RNA Seq Atlas | 615785 | ||||||||