Version 5.4
Bos taurus Gene: PINK1
Summary
InnateDB Gene IDBG-645657.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PINK1
Gene Name serine/threonine-protein kinase PINK1, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006084
Encoded Proteins
IDBP-698385
serine/threonine-protein kinase PINK1, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158828:
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:132601302-132621738
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029455 ENSBTAP00000029455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0010857 calcium-dependent protein kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
GO:0055131 C3HC4-type RING finger domain binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0031396 regulation of protein ubiquitination
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0033603 positive regulation of dopamine secretion
GO:0033605 positive regulation of catecholamine secretion
GO:0035556 intracellular signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein complex assembly
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097237 cellular response to toxic substance
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158828
View Gene Order
ENSMUSG00000028756
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
mmu05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A5PJP5
UniProt Splice Variant
Entrez Gene 510683
UniGene Bt.13259
RefSeq NM_001099701
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142192 DAAA02006489 DAAA02006490
GenPept AAI42193
RNA Seq Atlas 510683

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca