InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DAD1

Summary

InnateDB Gene

IDBG-645895.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAD1

Gene Name

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019077

Encoded Proteins

IDBP-698648

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129562:
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:22073358-22095132

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025397

ENSBTAP00000025397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004576	oligosaccharyl transferase activity
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups

Biological Process

GO:0001824	blastocyst development
GO:0006486	protein glycosylation
GO:0006915	apoptotic process
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000129562

View Gene Order

ENSMUSG00000022174

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_22161

Post-translational protein modification pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

mmu00510

N-Glycan biosynthesis pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

Q5E9C2

TrEMBL

UniProt Splice Variant

Entrez Gene

614538

UniGene

Bt.30555

RefSeq

NM_001034761

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY227782 BC102081 BT020998

GenPept

AAI02082 AAT39322 AAX09015

RNA Seq Atlas

614538