InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TYRO3

Summary

InnateDB Gene

IDBG-646302.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYRO3

Gene Name

tyrosine-protein kinase receptor TYRO3 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001694

Encoded Proteins

IDBP-699095

TYRO3 protein tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18083102

[Homo sapiens] Tyrosine protein kinase that acts with AXL and MERTK as pleiotropic inhibitor of the innate immune response in DCs

PMID 23954153

[Mus musculus] Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092445:
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:37078592-37095809

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002222

ENSBTAP00000002222

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001779	natural killer cell differentiation
GO:0006468	protein phosphorylation
GO:0007283	spermatogenesis
GO:0016310	phosphorylation
GO:0021885	forebrain cell migration
GO:0030168	platelet activation
GO:0032940	secretion by cell
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042698	ovulation cycle
GO:0043277	apoptotic cell clearance
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0045824	negative regulation of innate immune response
GO:0046777	protein autophosphorylation
GO:0050728	negative regulation of inflammatory response
GO:0051250	negative regulation of lymphocyte activation
GO:0060068	vagina development
GO:0070050	neuron cellular homeostasis
GO:0070527	platelet aggregation

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000092445

View Gene Order

ENSMUSG00000027298

View Gene Order

Cross-References

SwissProt

TrEMBL

F1N5L4

UniProt Splice Variant

Entrez Gene

788224

UniGene

Bt.729

RefSeq

NM_001191228 XM_005211620 XM_005211621

HUGO

HGNC:12446

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02028563

GenPept

RNA Seq Atlas

788224