InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SNAP23

Summary

InnateDB Gene

IDBG-646359.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAP23

Gene Name

synaptosomal-associated protein 23

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005661

Encoded Proteins

IDBP-699155

synaptosomal-associated protein 23

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18692471

[Homo sapiens] SNAP23 phosphorylation by IKBKB regulates mast cell degranulation and anaphylactic reactions.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092531:
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:37946231-37986849

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007438

ENSBTAP00000007438

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006887	exocytosis
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031410	cytoplasmic vesicle
GO:0042581	specific granule
GO:0042582	azurophil granule
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome