InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.49400

Summary

InnateDB Gene

IDBG-646370.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49400

Gene Name

methyl-CpG-binding domain protein 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021645

Encoded Proteins

IDBP-699166

methyl-CpG-binding domain protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129071:
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:56949105-56958155

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028844

ENSBTAP00000028844

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity

Biological Process

GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314	response to radiation