InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITK

Summary

InnateDB Gene

IDBG-646384.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITK

Gene Name

tyrosine-protein kinase ITK/TSK

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000306

Encoded Proteins

IDBP-699186

tyrosine-protein kinase ITK/TSK

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113263:
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:70911162-70973272

Strand

Forward strand

Band

Transcripts

ENSBTAT00000035086

ENSBTAP00000034966

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001816	cytokine production
GO:0001865	NK T cell differentiation
GO:0002250	adaptive immune response
GO:0006468	protein phosphorylation
GO:0007202	activation of phospholipase C activity
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032609	interferon-gamma production
GO:0032633	interleukin-4 production
GO:0035556	intracellular signal transduction
GO:0050852	T cell receptor signaling pathway