Bos taurus Gene: B2M
Summary
InnateDB Gene IDBG-646936.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B2M
Gene Name Beta-2-microglobulin
Synonyms B2M;
Species Bos taurus
Ensembl Gene ENSBTAG00000012330
Encoded Proteins
Beta-2-microglobulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166710:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:104139090-104145312
Strand Forward strand
Band
Transcripts
ENSBTAT00000016359 ENSBTAP00000016359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001895 retina homeostasis
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002237 response to molecule of bacterial origin
GO:0002376 immune system process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0033077 T cell differentiation in thymus
GO:0042026 protein refolding
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0042612 MHC class I protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DAP12 interactions pathway
Amyloids pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Adaptive Immune System pathway
Innate Immune System pathway
DAP12 signaling pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DAP12 signaling pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Endosomal/Vacuolar pathway pathway
ER-Phagosome pathway pathway
Amyloids pathway
Interferon Signaling pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Interferon gamma signaling pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
Nef mediated downregulation of MHC class I complex cell surface expression pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
DAP12 interactions pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Amyloids pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
ER-Phagosome pathway pathway
Endosomal/Vacuolar pathway pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
DAP12 interactions pathway
DAP12 signaling pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
KEGG
Antigen processing and presentation pathway
Antigen processing and presentation pathway
INOH
PID BIOCARTA
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
Antigen processing and presentation [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
Cross-References
SwissProt P01888
TrEMBL Q6VUQ8 Q862Q3
UniProt Splice Variant
Entrez Gene 783680
UniGene
RefSeq XM_001251107 XM_002691119
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB098926 AY325772 AY911322 BC118352 X69084
GenPept AAI18353 AAP78964 AAW82090 BAC56416 CAA48828
RNA Seq Atlas 280729 783680