Version 5.4
Bos taurus Gene: SOX2
Summary
InnateDB Gene IDBG-647279.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX2
Gene Name transcription factor SOX-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011598
Encoded Proteins
IDBP-700117
SRY (sex determining region Y)-box 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181449:
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:85933323-85934782
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015411 ENSBTAP00000015411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001708 cell fate specification
GO:0001714 endodermal cell fate specification
GO:0002052 positive regulation of neuroblast proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007050 cell cycle arrest
GO:0007605 sensory perception of sound
GO:0009611 response to wounding
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0019827 stem cell maintenance
GO:0021879 forebrain neuron differentiation
GO:0021983 pituitary gland development
GO:0021984 adenohypophysis development
GO:0021987 cerebral cortex development
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030539 male genitalia development
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030910 olfactory placode formation
GO:0032526 response to retinoic acid
GO:0035019 somatic stem cell maintenance
GO:0042472 inner ear morphogenesis
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043586 tongue development
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046148 pigment biosynthetic process
GO:0048286 lung alveolus development
GO:0048568 embryonic organ development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048663 neuron fate commitment
GO:0048839 inner ear development
GO:0048852 diencephalon morphogenesis
GO:0048863 stem cell differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0050973 detection of mechanical stimulus involved in equilibrioception
GO:0060042 retina morphogenesis in camera-type eye
GO:0060235 lens induction in camera-type eye
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0070848 response to growth factor
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000181449
View Gene Order
ENSMUSG00000074637
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_200759
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
REACT_200670
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2VDX8
UniProt Splice Variant
Entrez Gene 784383
UniGene Bt.103364
RefSeq NM_001105463
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133458 DAAA02001921
GenPept AAI33459
RNA Seq Atlas 784383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca