Version 5.4
Homo sapiens Gene: SMURF2
Summary
InnateDB Gene IDBG-64876.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMURF2
Gene Name SMAD specific E3 ubiquitin protein ligase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108854
Encoded Proteins
IDBP-64878
SMAD specific E3 ubiquitin protein ligase 2
IDBP-758303
IDBP-761349
IDBP-760929
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64542295-64662068
Strand Reverse strand
Band q24.1
Transcripts
ENST00000262435 ENSP00000262435
ENST00000580072
ENST00000578386 ENSP00000464432
ENST00000582081 ENSP00000463531
ENST00000578200
ENST00000580246
ENST00000585301 ENSP00000463804
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 226 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 226 [view]
Protein-Protein 226 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046332 SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010467 gene expression
GO:0016567 protein ubiquitination
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018363
View Gene Order
ENSBTAG00000019853
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_12034
Signaling by BMP pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_172581
PCP/CE pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_200766
degradation of AXIN pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04144
Endocytosis pathway
INOH
INOH website
TGF-beta signaling pathway
PID NCI
bmppathway
BMP receptor signaling
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL J3QRY2
UniProt Splice Variant
Entrez Gene 64750
UniGene Hs.515011 Hs.635051 Hs.720886 Hs.743661
RefSeq NM_022739 XM_005257585
HUGO HGNC:16809
OMIM 605532
CCDS CCDS32707
HPRD 06901
IMGT
EMBL AC009994 AC132812
GenPept
RNA Seq Atlas 64750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca