Version 5.4
Homo sapiens Gene: UVRAG
Summary
InnateDB Gene IDBG-65034.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UVRAG
Gene Name UV radiation resistance associated
Synonyms DHTX; p63; VPS38
Species Homo sapiens
Ensembl Gene ENSG00000198382
Encoded Proteins
IDBP-65038
UV radiation resistance associated gene
IDBP-599153
UV radiation resistance associated gene
IDBP-598540
UV radiation resistance associated gene
IDBP-599682
UV radiation resistance associated gene
IDBP-588154
UV radiation resistance associated gene
IDBP-601449
UV radiation resistance associated gene
IDBP-591241
UV radiation resistance associated gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25917095
[Mus musculus] Mir125a regulates the innate host defense by inhibiting the activation of autophagy and antimicrobial effects against Mycobacterium tuberculosis through targeting Uvrag.
Entrez Gene
Summary This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:75815167-76143195
Strand Forward strand
Band q13.5
Transcripts
ENST00000356136 ENSP00000348455
ENST00000528420 ENSP00000436039
ENST00000528264 ENSP00000433613
ENST00000525872
ENST00000533454 ENSP00000431256
ENST00000530501
ENST00000531818 ENSP00000434082
ENST00000532130 ENSP00000436270
ENST00000525183 ENSP00000433414
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006281 DNA repair
GO:0010508 positive regulation of autophagy
GO:0035493 SNARE complex assembly
GO:0046718 viral entry into host cell
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035354
View Gene Order
ENSBTAG00000016355
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.202470 Hs.741452
RefSeq NM_003369 XM_006718674
HUGO
OMIM
CCDS CCDS8241
HPRD 03929
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca