Version 5.4
Homo sapiens Gene: PLP2
Summary
InnateDB Gene IDBG-65641.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLP2
Gene Name proteolipid protein 2 (colonic epithelium-enriched)
Synonyms A4; A4LSB
Species Homo sapiens
Ensembl Gene ENSG00000102007
Encoded Proteins
IDBP-65643
proteolipid protein 2 (colonic epithelium-enriched)
IDBP-65645
proteolipid protein 2 (colonic epithelium-enriched)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:49171926-49175239
Strand Forward strand
Band p11.23
Transcripts
ENST00000376327 ENSP00000365505
ENST00000376322 ENSP00000365500
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015075 ion transmembrane transporter activity
GO:0019956 chemokine binding
Biological Process
GO:0006811 ion transport
GO:0006935 chemotaxis
GO:0019221 cytokine-mediated signaling pathway
GO:0034220 ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q04941
TrEMBL A0A024QYW3
UniProt Splice Variant
Entrez Gene 5355
UniGene
RefSeq NM_002668
HUGO HGNC:9087
OMIM 300112
CCDS CCDS14319
HPRD
IMGT
EMBL AF196779 BC109066 CH471224 DB102321 L09604 U93305
GenPept AAA35499 AAB92356 AAI09067 EAW50689 EAW50690
RNA Seq Atlas 5355

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca