Homo sapiens Gene: CLNS1A
Summary
InnateDB Gene IDBG-65661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLNS1A
Gene Name chloride channel, nucleotide-sensitive, 1A
Synonyms CLCI; CLNS1B; ICln;
Species Homo sapiens
Ensembl Gene ENSG00000074201
Encoded Proteins
chloride channel, nucleotide-sensitive, 1A
chloride channel, nucleotide-sensitive, 1A
chloride channel, nucleotide-sensitive, 1A
chloride channel, nucleotide-sensitive, 1A
chloride channel, nucleotide-sensitive, 1A
chloride channel, nucleotide-sensitive, 1A
chloride channel, nucleotide-sensitive, 1A
chloride channel, nucleotide-sensitive, 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:77514936-77637805
Strand Reverse strand
Band q14.1
Transcripts
ENST00000263309 ENSP00000263309
ENST00000526761 ENSP00000475218
ENST00000533957
ENST00000525428 ENSP00000433919
ENST00000525064 ENSP00000433741
ENST00000526009 ENSP00000436245
ENST00000532069 ENSP00000434963
ENST00000527133 ENSP00000432570
ENST00000528364 ENSP00000434311
ENST00000527299
ENST00000525359
ENST00000527265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
Experimentally validated
Total 94 [view]
Protein-Protein 93 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0006821 chloride transport
GO:0006884 cell volume homeostasis
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0034660 ncRNA metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0034709 methylosome
GO:0034715 pICln-Sm protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of non-coding RNA pathway
snRNP Assembly pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.430733 Hs.656608
RefSeq NM_001293
HUGO
OMIM
CCDS CCDS8252
HPRD 03694
IMGT
EMBL
GenPept
RNA Seq Atlas