Version 5.4
Homo sapiens Gene: SIGLEC7
Summary
InnateDB Gene IDBG-65680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC7
Gene Name sialic acid binding Ig-like lectin 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168995
Encoded Proteins
IDBP-65682
sialic acid binding Ig-like lectin 7
IDBP-65684
sialic acid binding Ig-like lectin 7
IDBP-585350
sialic acid binding Ig-like lectin 7
IDBP-765085
IDBP-760766
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21208791
SIGLEC7 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51142299-51153526
Strand Forward strand
Band q13.41
Transcripts
ENST00000305628 ENSP00000306757
ENST00000317643 ENSP00000323328
ENST00000536156 ENSP00000437609
ENST00000599250
ENST00000600577 ENSP00000472529
ENST00000601682 ENSP00000469626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655393
RefSeq NM_001277201 NM_014385 NM_016543 XM_006723140
HUGO
OMIM
CCDS CCDS12826 CCDS42601 CCDS62771
HPRD 05102
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca