Homo sapiens Gene: PRKAR1A
InnateDB Gene IDBG-65907.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAR1A
Gene Name protein kinase, cAMP-dependent, regulatory, type I, alpha
Species Homo sapiens
Ensembl Gene ENSG00000108946
Encoded Proteins
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:68511780-68551319
Strand Forward strand
Band q24.2
ENST00000358598 ENSP00000351410
ENST00000392711 ENSP00000376475
ENST00000392710 ENSP00000376474
ENST00000536854 ENSP00000445625
ENST00000585981 ENSP00000467311
ENST00000585815 ENSP00000467867
ENST00000588178 ENSP00000465013
ENST00000585427 ENSP00000464715
ENST00000586541 ENSP00000465740
ENST00000589017 ENSP00000465445
ENST00000588702 ENSP00000464701
ENST00000589480 ENSP00000466649
ENST00000586397 ENSP00000466459
ENST00000589309 ENSP00000467500
ENST00000585608 ENSP00000466722
ENST00000589228 ENSP00000464977
ENST00000588188 ENSP00000468106
ENST00000592800 ENSP00000466314
Number of Interactions This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 92 [view]
Protein-Protein 89 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
GO:0005515 protein binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0030552 cAMP binding
GO:0031625 ubiquitin protein ligase binding
GO:0034236 protein kinase A catalytic subunit binding
Biological Process
GO:0001707 mesoderm formation
GO:0001932 regulation of protein phosphorylation
GO:0006112 energy reserve metabolic process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0006833 water transport
GO:0007143 female meiotic division
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045214 sarcomere organization
GO:0045835 negative regulation of meiosis
GO:0045859 regulation of protein kinase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050796 regulation of insulin secretion
GO:0055085 transmembrane transport
GO:0060038 cardiac muscle cell proliferation
GO:0071377 cellular response to glucagon stimulus
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
GO:0031588 AMP-activated protein kinase complex
GO:0031594 neuromuscular junction
GO:0043234 protein complex
Mus musculus
Bos taurus
Gene ID
Gene Order
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
EGFR1 pathway
FSH pathway
Signaling by FGFR in disease pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
CaM pathway pathway
Signalling by NGF pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Phospholipase C-mediated cascade pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
Glucagon signaling in metabolic regulation pathway
PLC-gamma1 signalling pathway
Opioid Signalling pathway
DAG and IP3 signaling pathway
PKA activation pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
Factors involved in megakaryocyte development and platelet production pathway
Signaling by FGFR pathway
Regulation of insulin secretion pathway
Signaling by PDGF pathway
PKA activation in glucagon signalling pathway
Signaling by ERBB2 pathway
Metabolism pathway
DARPP-32 events pathway
PLCG1 events in ERBB2 signaling pathway
Ca-dependent events pathway
Calmodulin induced events pathway
Aquaporin-mediated transport pathway
Disease pathway
Hemostasis pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
Apoptosis pathway
Insulin signaling pathway pathway
GPCR signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
Signaling pathway from g-protein families [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Phospholipase c-epsilon pathway [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Attenuation of gpcr signaling [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Repression of pain sensation by the transcriptional regulator dream [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Nitric oxide signaling pathway [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
Stathmin and breast cancer resistance to antimicrotubule agents [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Transcription regulation by methyltransferase of carm1 [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
Alpha4 beta1 integrin signaling events
UniProt Splice Variant
Entrez Gene
UniGene Hs.280342 Hs.608196 Hs.685590 Hs.733388
RefSeq NM_001276289 NM_001276290 NM_001278433 NM_002734 NM_212471 NM_212472
CCDS CCDS11678 CCDS62307
HPRD 01786
RNA Seq Atlas