InnateDB: Systems Biology of the Innate Immune Response

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:68511780-68551319

Strand

Forward strand

Band

q24.2

Transcripts

ENST00000358598	ENSP00000351410
ENST00000392711	ENSP00000376475
ENST00000392710	ENSP00000376474
ENST00000536854	ENSP00000445625
ENST00000585981	ENSP00000467311
ENST00000592194
ENST00000585815	ENSP00000467867
ENST00000588178	ENSP00000465013
ENST00000585460
ENST00000585427	ENSP00000464715
ENST00000586541	ENSP00000465740
ENST00000589017	ENSP00000465445
ENST00000588702	ENSP00000464701
ENST00000589480	ENSP00000466649
ENST00000585907
ENST00000586397	ENSP00000466459
ENST00000589309	ENSP00000467500
ENST00000585608	ENSP00000466722
ENST00000589228	ENSP00000464977
ENST00000588188	ENSP00000468106
ENST00000590353
ENST00000592800	ENSP00000466314

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	92 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0005515	protein binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0034236	protein kinase A catalytic subunit binding

Biological Process

GO:0001707	mesoderm formation
GO:0001932	regulation of protein phosphorylation
GO:0006112	energy reserve metabolic process
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0006833	water transport
GO:0007143	female meiotic division
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0045214	sarcomere organization
GO:0045835	negative regulation of meiosis
GO:0045859	regulation of protein kinase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0060038	cardiac muscle cell proliferation
GO:0071377	cellular response to glucagon stimulus
GO:2000480	negative regulation of cAMP-dependent protein kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005952	cAMP-dependent protein kinase complex
GO:0016020	membrane
GO:0031588	AMP-activated protein kinase complex
GO:0031594	neuromuscular junction
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020612

View Gene Order

ENSBTAG00000008621

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_25

FSH pathway

REACTOME

REACT_15530

PKA activation pathway

REACT_15497

PKA-mediated phosphorylation of CREB pathway

REACT_9000

Calmodulin induced events pathway

REACT_9053

CaM pathway pathway

REACT_111064

DAG and IP3 signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_12079

PLC-gamma1 signalling pathway

REACT_12478

EGFR interacts with phospholipase C-gamma pathway

REACT_9417

Signaling by EGFR pathway

REACT_15426

PLC beta mediated events pathway

REACT_15334

DARPP-32 events pathway

REACT_15295

Opioid Signalling pathway

REACT_115720

PLCG1 events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_18274

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1946

PKA activation in glucagon signalling pathway

REACT_1665

Glucagon signaling in metabolic regulation pathway

REACT_1505

Integration of energy metabolism pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_11061

Signalling by NGF pathway

REACT_228134

Signaling by Hedgehog pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_15526

G-protein mediated events pathway

REACT_6900

Immune System pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_111217

Metabolism pathway

REACT_15307

Ca-dependent events pathway

REACT_23887

Aquaporin-mediated transport pathway

REACT_116125

Disease pathway

REACT_604

Hemostasis pathway

KEGG

hsa04210

Apoptosis pathway

hsa04910

Insulin signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

GPCR Adenosine A2A receptor signaling pathway pathway

INOH website

VEGF signaling pathway pathway

INOH website

GPCR Dopamine D1like receptor signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

integrin_a4b1_pathway

Alpha4 beta1 integrin signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.280342 Hs.608196 Hs.685590 Hs.733388

RefSeq

NM_001276289 NM_001276290 NM_001278433 NM_002734 NM_212471 NM_212472

HUGO

OMIM

CCDS

CCDS11678 CCDS62307

HPRD

01786

IMGT

EMBL

GenPept

RNA Seq Atlas