Version 5.4
| Homo sapiens Gene: DEFB106A | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-6616.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | DEFB106A | ||||||||||||||||||
| Gene Name | defensin, beta 106A | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000186579 | ||||||||||||||||||
| Encoded Proteins |
defensin, beta 106A
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106B, represents the more telomeric copy. [provided by RefSeq, Jul 2008] Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:7825172-7829053 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p23.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Beta defensins pathway
Defensins pathway
Innate Immune System pathway
Immune System pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q8N104 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 503841 | ||||||||||||||||||
| UniGene | Hs.511958 Hs.535925 | ||||||||||||||||||
| RefSeq | NM_152251 | ||||||||||||||||||
| HUGO | HGNC:18088 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS34833 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB089181 AF529417 AF540978 AY122466 BC100844 BC100845 BC100846 BC100847 BC110062 BC111688 | ||||||||||||||||||
| GenPept | AAI00845 AAI00846 AAI00847 AAI00848 AAI10063 AAI11689 AAM93908 AAN33114 AAQ09526 BAC10631 | ||||||||||||||||||
| RNA Seq Atlas | 245909 503841 | ||||||||||||||||||