Version 5.4
Homo sapiens Gene: ACTL6A
Summary
InnateDB Gene IDBG-66303.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTL6A
Gene Name actin-like 6A
Synonyms ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K
Species Homo sapiens
Ensembl Gene ENSG00000136518
Encoded Proteins
IDBP-245189
actin-like 6A
IDBP-385647
actin-like 6A
IDBP-385649
actin-like 6A
IDBP-478388
actin-like 6A
IDBP-473847
actin-like 6A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:179562880-179588408
Strand Forward strand
Band q26.33
Transcripts
ENST00000392662 ENSP00000376430
ENST00000429709 ENSP00000397552
ENST00000450518 ENSP00000394014
ENST00000491202
ENST00000468767
ENST00000494843
ENST00000490364 ENSP00000420153
ENST00000487978 ENSP00000420694
ENST00000486471
ENST00000467383
ENST00000467615
ENST00000479056
ENST00000484312
ENST00000461125
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 85 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0003407 neural retina development
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0040008 regulation of growth
GO:0043044 ATP-dependent chromatin remodeling
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0016514 SWI/SNF complex
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0043234 protein complex
GO:0071564 npBAF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027671
View Gene Order
ENSBTAG00000002460
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
myc_pathway
C-MYC pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435326
RefSeq NM_004301 NM_177989 NM_178042
HUGO
OMIM
CCDS CCDS3231 CCDS43174
HPRD 05389
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca