Homo sapiens Gene: NDUFB5
Summary
InnateDB Gene IDBG-66419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFB5
Gene Name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
Synonyms CISGDH; SGDH;
Species Homo sapiens
Ensembl Gene ENSG00000136521
Encoded Proteins
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:179604690-179627647
Strand Forward strand
Band q26.33
Transcripts
ENST00000259037 ENSP00000259037
ENST00000359944 ENSP00000353026
ENST00000488002
ENST00000493866 ENSP00000419656
ENST00000472629 ENSP00000419248
ENST00000468210 ENSP00000420538
ENST00000477177
ENST00000482604 ENSP00000418354
ENST00000480374 ENSP00000419099
ENST00000496904
ENST00000473500
ENST00000491054
ENST00000471112 ENSP00000419501
ENST00000476587
ENST00000493716
ENST00000611971 ENSP00000481703
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 14 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.730674
RefSeq NM_001199957 NM_001199958 NM_002492
HUGO
OMIM
CCDS CCDS3234 CCDS56297 CCDS75054
HPRD 11956
IMGT
EMBL
GenPept
RNA Seq Atlas