Version 5.4
Homo sapiens Gene: MAP2K6
Summary
InnateDB Gene IDBG-66516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K6
Gene Name mitogen-activated protein kinase kinase 6
Synonyms MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3
Species Homo sapiens
Ensembl Gene ENSG00000108984
Encoded Proteins
IDBP-66518
mitogen-activated protein kinase kinase 6
IDBP-763098
IDBP-761869
IDBP-759370
IDBP-760463
IDBP-811654
mitogen-activated protein kinase kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 9841871
MAP2K6 activates MAPK14 (p38) MAP kinases.
Entrez Gene
Summary This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:69414698-69543331
Strand Forward strand
Band q24.3
Transcripts
ENST00000359094 ENSP00000351997
ENST00000590474 ENSP00000468348
ENST00000589295 ENSP00000466143
ENST00000588110 ENSP00000464916
ENST00000586641
ENST00000589647 ENSP00000467213
ENST00000592348
ENST00000591445
ENST00000613873 ENSP00000477701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0002931 response to ischemia
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006975 DNA damage induced protein phosphorylation
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0022602 ovulation cycle process
GO:0032308 positive regulation of prostaglandin secretion
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 response to drug
GO:0042692 muscle cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051149 positive regulation of muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060048 cardiac muscle contraction
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0072709 cellular response to sorbitol
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020623
View Gene Order
ENSBTAG00000001609
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_13
IL1 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
REACTOME
REACT_21399
activated TAK1 mediates p38 MAPK activation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_21402
CDO in myogenesis pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_21303
Myogenesis pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_22232
Signaling by Interleukins pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04380
Osteoclast differentiation pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
anthraxpathway
Cellular roles of Anthrax toxin
il1pathway
IL1-mediated signaling events
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
p38alphabetapathway
Regulation of p38-alpha and p38-beta
ar_tf_pathway
Regulation of Androgen receptor activity
il6_7pathway
IL6-mediated signaling events
faspathway
FAS (CD95) signaling pathway
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463978
RefSeq NM_002758 XM_005257517 XM_006721975
HUGO
OMIM
CCDS CCDS11686
HPRD 03155
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca