Homo sapiens Gene: IL37
InnateDB Gene IDBG-66559.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL37
Gene Name interleukin 37
Species Homo sapiens
Ensembl Gene ENSG00000125571
Encoded Proteins
interleukin 37
interleukin 37
interleukin 37
interleukin 37
interleukin 37
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
IL1F7 (IL-37) is a natural suppressor of innate inflammatory and immune responses. IL1F7 expression in macrophages or epithelial cells suppresses production of pro-inflammatory cytokines and the abundance of these cytokines increases with silencing of endogenous IL1F7 in human blood cells.
IL1F7 functions as a key modulator of intestinal inflammation where transgenic mice expressing IL1F7 subjected to dextran sulfate sodium-induced colitis showed reduced inflammation which was associated with decreased leukocyte recruitment into the colonic lamina propria. (Demonstrated in murine model)
The precursor and mature forms of IL37 are secreted from activated cells upon inflammasome activation and CASP1 processing of IL37 is important for its anti-inflammatory activity.
IL37 acts as an extracellular cytokine to inhibit innate inflammation by binding to IL18R1 and then using IL1RAPL1 for its anti-inflammatory properties.
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:112912971-112918882
Strand Forward strand
Band q14.1
ENST00000263326 ENSP00000263326
ENST00000352179 ENSP00000263327
ENST00000353225 ENSP00000309208
ENST00000349806 ENSP00000263328
ENST00000311328 ENSP00000309883
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
No orthologs found for this gene
SwissProt Q9NZH6
UniProt Splice Variant
Entrez Gene 27178
UniGene Hs.166371
RefSeq NM_173205 NM_014439 NM_173202 NM_173203 NM_173204
OMIM 605510
CCDS CCDS2107 CCDS2103 CCDS2104 CCDS2105 CCDS2106
HPRD 05695
EMBL AB451333 AB451478 AC079753 AF167368 AF200496 AF201832 AF251118 AF251119 AF251120 AY071840 AY071841 AY973625 BC020637 CH471217
GenPept AAF25212 AAF69252 AAG14420 AAG14421 AAG14422 AAG29344 AAH20637 AAL67151 AAL67154 AAX59036 AAX88889 BAG70147 BAG70292 EAW73609
RNA Seq Atlas 27178