InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP3K8

Summary

InnateDB Gene

IDBG-66703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K8

Gene Name

mitogen-activated protein kinase kinase kinase 8

Synonyms

c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2

Species

Homo sapiens

Ensembl Gene

ENSG00000107968

Encoded Proteins

IDBP-66707

mitogen-activated protein kinase kinase kinase 8

IDBP-66709

mitogen-activated protein kinase kinase kinase 8

IDBP-66711

mitogen-activated protein kinase kinase kinase 8

IDBP-371691

mitogen-activated protein kinase kinase kinase 8

IDBP-371698

mitogen-activated protein kinase kinase kinase 8

IDBP-584780

mitogen-activated protein kinase kinase kinase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19667062

MAP3K8 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.

PMID 19933865

MAP3K8 is essential for IL-1beta production from both macrophages and dendritic cells and an important mediator for collaboration of pattern recognition receptors with danger-associated molecular patterns (DAMPs) to induce TNF and IL-1beta production and optimal host defence.

PMID 20405269

MAP3K8 regulates IL23A expression in lipopolysaccharide (LPS)-stimulated macrophages through extracellular signal-regulated kinase (ERK) activation.

PMID 21135874

MAP3K8 is a MEK kinase that is require for the activation of MAP kinases in myeloid cells following TLR and TNF receptor stimulation. MAP3K8 is critical for production of the pro-inflammatory cytokine TNF during inflammatory responses.

InnateDB Annotation from Orthologs

Summary

PMID 21135874

[Mus musculus] Map3k8 is a MEK kinase that is require for the activation of MAP kinases in myeloid cells following TLR and TNF receptor stimulation. Map3k8 is critical for production of the pro-inflammatory cytokine TNF during inflammatory responses.

PMID 26241898

[Mus musculus] Map3k8 plays a role in facilitating both innate and adaptive antiviral responses by transducing Type I interferon (IFN) signals and promoting expression of IFN-stimulated genes (ISGs).

Entrez Gene

Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:30433937-30461833

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000263056	ENSP00000263056
ENST00000375322	ENSP00000364471
ENST00000375321	ENSP00000364470
ENST00000415139	ENSP00000409653
ENST00000413724	ENSP00000391275
ENST00000430603
ENST00000542547	ENSP00000443610

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0031295	T cell costimulation
GO:0045087	innate immune response (InnateDB)