InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP11B

Summary

InnateDB Gene

IDBG-66738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP11B

Gene Name

ATPase, class VI, type 11B

Synonyms

ATPIF; ATPIR

Species

Homo sapiens

Ensembl Gene

ENSG00000058063

Encoded Proteins

IDBP-66740

ATPase, class VI, type 11B

IDBP-481119

ATPase, class VI, type 11B

IDBP-480935

ATPase, class VI, type 11B

IDBP-477003

ATPase, class VI, type 11B

IDBP-474173

ATPase, class VI, type 11B

IDBP-476797

ATPase, class VI, type 11B

IDBP-483681

ATPase, class VI, type 11B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:182793500-182921635

Strand

Forward strand

Band

q26.33

Transcripts

ENST00000323116	ENSP00000321195
ENST00000493826	ENSP00000419032
ENST00000482794
ENST00000498086	ENSP00000418421
ENST00000490303
ENST00000466758	ENSP00000417406
ENST00000482070	ENSP00000417124
ENST00000491699	ENSP00000419768
ENST00000484691	ENSP00000419152
ENST00000475636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015075	ion transmembrane transporter activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006811	ion transport
GO:0006812	cation transport
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0015917	aminophospholipid transport
GO:0034220	ion transmembrane transport
GO:0045332	phospholipid translocation
GO:0055085	transmembrane transport

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037400

View Gene Order

ENSBTAG00000000290

Not yet available

Pathways

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.478429 Hs.619369

RefSeq

NM_014616 XM_005247243

HUGO

OMIM

CCDS

CCDS33896

HPRD

10432

IMGT

EMBL

GenPept

RNA Seq Atlas