Version 5.4
Homo sapiens Gene: LGALS2
Summary
InnateDB Gene IDBG-6696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS2
Gene Name lectin, galactoside-binding, soluble, 2
Synonyms HL14
Species Homo sapiens
Ensembl Gene ENSG00000100079
Encoded Proteins
IDBP-6698
lectin, galactoside-binding, soluble, 2
IDBP-375458
lectin, galactoside-binding, soluble, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 15356130
LGASL2 binds to T cells in a beta-galactoside-specific manner and acts as pro-apoptotic effector for activated T cells.
Entrez Gene
Summary The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37570246-37582616
Strand Reverse strand
Band q13.1
Transcripts
ENST00000215886 ENSP00000215886
ENST00000416480 ENSP00000407351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016936 galactoside binding
GO:0030246 carbohydrate binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043501
View Gene Order
ENSBTAG00000021615
Not yet available
Cross-References
SwissProt
TrEMBL B0QYC9
UniProt Splice Variant
Entrez Gene 3957
UniGene
RefSeq NM_006498
HUGO HGNC:6562
OMIM 150571
CCDS CCDS13950
HPRD 08859
IMGT
EMBL AL022315
GenPept
RNA Seq Atlas 3957

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca