Homo sapiens Gene: LGALS2
Summary
InnateDB Gene IDBG-6696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS2
Gene Name lectin, galactoside-binding, soluble, 2
Synonyms HL14;
Species Homo sapiens
Ensembl Gene ENSG00000100079
Encoded Proteins
lectin, galactoside-binding, soluble, 2
lectin, galactoside-binding, soluble, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LGASL2 binds to T cells in a beta-galactoside-specific manner and acts as pro-apoptotic effector for activated T cells.
Entrez Gene
Summary The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37570246-37582616
Strand Reverse strand
Band q13.1
Transcripts
ENST00000215886 ENSP00000215886
ENST00000416480 ENSP00000407351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016936 galactoside binding
GO:0030246 carbohydrate binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL B0QYC9
UniProt Splice Variant
Entrez Gene 3957
UniGene
RefSeq NM_006498
HUGO HGNC:6562
OMIM 150571
CCDS CCDS13950
HPRD 08859
IMGT
EMBL AL022315
GenPept
RNA Seq Atlas 3957