InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ME3

Summary

InnateDB Gene

IDBG-66961.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ME3

Gene Name

malic enzyme 3, NADP(+)-dependent, mitochondrial

Synonyms

NADP-ME

Species

Homo sapiens

Ensembl Gene

ENSG00000151376

Encoded Proteins

IDBP-66965

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-243847

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-602299

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-599602

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-602857

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-589755

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-585539

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-584395

malic enzyme 3, NADP(+)-dependent, mitochondrial

IDBP-593681

malic enzyme 3, NADP(+)-dependent, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:86441108-86672636

Strand

Reverse strand

Band

q14.2

Transcripts

ENST00000323418	ENSP00000315255
ENST00000393324	ENSP00000376998
ENST00000524826	ENSP00000431182
ENST00000530520
ENST00000526504	ENSP00000433636
ENST00000525957
ENST00000530335	ENSP00000434690
ENST00000534638
ENST00000532471	ENSP00000435427
ENST00000526834	ENSP00000437204
ENST00000526944	ENSP00000434431
ENST00000543262	ENSP00000440246

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004470	malic enzyme activity
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0008948	oxaloacetate decarboxylase activity
GO:0046872	metal ion binding
GO:0048037	cofactor binding
GO:0051287	NAD binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006108	malate metabolic process
GO:0009060	aerobic respiration
GO:0055114	oxidation-reduction process
GO:0072592	oxygen metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030621

View Gene Order

ENSBTAG00000000246

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00620

Pyruvate metabolism pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

INOH website

Pyruvate metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.199743

RefSeq

NM_001014811 NM_001161586 NM_006680 XM_005273717

HUGO

OMIM

CCDS

CCDS8277

HPRD

06862

IMGT

EMBL

GenPept

RNA Seq Atlas