InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCC5

Summary

InnateDB Gene

IDBG-67159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC5

Gene Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Synonyms

ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP

Species

Homo sapiens

Ensembl Gene

ENSG00000114770

Encoded Proteins

IDBP-67161

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-67163

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-67167

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-245348

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-385831

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-385833

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-385835

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-385836

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-385837

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-385838

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

IDBP-385839

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:183919934-184018015

Strand

Reverse strand

Band

q27.1

Transcripts

ENST00000334444	ENSP00000333926
ENST00000265586	ENSP00000265586
ENST00000382494	ENSP00000371934
ENST00000392579	ENSP00000376358
ENST00000437205	ENSP00000403510
ENST00000443497	ENSP00000404302
ENST00000443376	ENSP00000416840
ENST00000438979	ENSP00000409913
ENST00000427120	ENSP00000404809
ENST00000437341	ENSP00000399726
ENST00000446941	ENSP00000390911
ENST00000476402
ENST00000492216

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008514	organic anion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015711	organic anion transport
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030213	hyaluronan biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport