Version 5.4
Homo sapiens Gene: GGA1
Summary
InnateDB Gene IDBG-6731.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGA1
Gene Name golgi-associated, gamma adaptin ear containing, ARF binding protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100083
Encoded Proteins
IDBP-6733
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-6737
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-6739
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375599
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-293809
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-293813
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375563
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375572
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375573
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375579
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375584
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375589
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375592
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375603
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
IDBP-375604
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37608475-37633564
Strand Forward strand
Band q13.1
Transcripts
ENST00000343632 ENSP00000341344
ENST00000325180 ENSP00000321288
ENST00000381756 ENSP00000371175
ENST00000326597 ENSP00000402930
ENST00000405147 ENSP00000384030
ENST00000406772 ENSP00000385287
ENST00000429218 ENSP00000403534
ENST00000439161 ENSP00000404453
ENST00000449944 ENSP00000390416
ENST00000411501 ENSP00000400159
ENST00000453208 ENSP00000416153
ENST00000447515 ENSP00000411727
ENST00000431745 ENSP00000395901
ENST00000413251 ENSP00000411373
ENST00000423024 ENSP00000414413
ENST00000489772
ENST00000484804
ENST00000488672
ENST00000491295
ENST00000481613
ENST00000475445
ENST00000463672
ENST00000460957
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 77 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030131 clathrin adaptor complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033128
View Gene Order
ENSBTAG00000006464
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499158 Hs.614497 Hs.656661
RefSeq NM_001001560 NM_001172687 NM_001172688 NM_013365 XM_005261518 XM_005261520 XM_006724229
HUGO
OMIM
CCDS CCDS13951 CCDS33643 CCDS54526
HPRD 12078
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca