Version 5.4
| Homo sapiens Gene: PSMD2 | |||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-67752.6 | ||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | PSMD2 | ||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | ||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | P97; RPN1; S2; TRAP2 | ||||||||||||||||||||||||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSG00000175166 | ||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||
| Summary |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008] The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 3:184298709-184309054 | ||||||||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||||||
| Band | q27.1 | ||||||||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 219 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
TNFalpha pathway
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| REACTOME |
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Stabilization of p53 pathway
p53-Dependent G1 DNA Damage Response pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
p53-Independent DNA Damage Response pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Separation of Sister Chromatids pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Switching of origins to a post-replicative state pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the pre-replicative complex pathway
Cyclin E associated events during G1/S transition pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
ER-Phagosome pathway pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Activation of NF-kappaB in B cells pathway
Degradation of beta-catenin by the destruction complex pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Regulation of ornithine decarboxylase (ODC) pathway
Vif-mediated degradation of APOBEC3G pathway
Vpu mediated degradation of CD4 pathway
DNA Replication pathway
PCP/CE pathway pathway
truncated APC mutants destabilize the destruction complex pathway
p53-Dependent G1/S DNA damage checkpoint pathway
p53-Independent G1/S DNA damage checkpoint pathway
Processing-defective Hh variants abrogate ligand secretion pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Synthesis of DNA pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Regulation of mitotic cell cycle pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
Ubiquitin-dependent degradation of Cyclin D pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Metabolism of amino acids and derivatives pathway
Immune System pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Hedgehog ligand biogenesis pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Asymmetric localization of PCP proteins pathway
M/G1 Transition pathway
degradation of AXIN pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
G1/S DNA Damage Checkpoints pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
Regulation of DNA replication pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Regulation of Apoptosis pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
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| KEGG |
Proteasome pathway
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| INOH |
TGF-beta signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Hs.518464 Hs.623484 Hs.654941 Hs.673369 Hs.693192 | ||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001278708 NM_001278709 NM_002808 | ||||||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS3258 CCDS63853 CCDS63854 | ||||||||||||||||||||||||||||||||||||||||||||
| HPRD | 05870 | ||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||